"Anemia is a common expression of Cu deficiency" (p. 75)
"Cu deficiency has never been reported in adult humans" (p. 93)
E. Underwood "Trace Elements in Human and Animal Nutrition" 4e
"Confirming previous studies, poorer iron status was notably more common in heavier participants. Independent of iron status, both BMI and inflammation (as measured by C-reactive protein) were negatively correlated with absorption of isotopically labeled iron from fortified foods. In addition, those with greater adiposity were unable to improve their iron status by dietary means compared to lean controls. Although hepcidin was not measured, it was suggested by the authors that inflammation-induced hepcidin was likely causing a decrease in dietary iron absorption by diminishing the expression of Fpn located on the basolateral membrane of intestinal enterocytes thus impairing dietary repletion efforts."
"Rethinking Iron Regulation and Assessment in Iron Deficiency, Anemia of Chronic Disease, and Obesity: Introducing Hepcidin" Lisa Tussing-Humphreys, PhD, RD, , Cenk Pustacioglu, Elizabeta Nemeth, PhD, Carol Braunschweig, PhD, RD
"Anemia of chronic disease (ACD, or anemia of inflammation) is the most prevalent anemia in hospitalized patients 1–3 and develops in subjects with diseases involving acute or chronic immune activation, such as infections, malignancies or autoimmune disorders"
Pathways for the regulation of hepcidin expression in anemia of chronic disease and iron deficiency anemia in vivo
Igor Theurl,1,* Andrea Schroll,1,* Manfred Nairz,1 Markus Seifert,1 Milan Theurl,1,2 Thomas Sonnweber,1 Hasan Kulaksiz,3 and Guenter Weiss1